首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Protein kinase C isozymes and addiction
Authors:M Foster Olive  Robert O Messing
Institution:(1) Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 94608 Emeryville, CA
Abstract:Protein kinase C (PKC) has long been recognized an important family of enzymes that regulate numerous aspects of neuronal signal transduction, neurotransmitter synthesis, release and reuptake, receptor and ion channel function, neuronal excitability, development, and gene expression. Much evidence has implicated PKCs in the effects of several drugs of abuse, and in behavioral responses to these drugs. The present review summarizes the effects of both acute and chronic exposure to various drugs of abuse on individual PKC isozymes in the brain. In addition, we summarize recent studies utilizing mice with targeted deletions of the genes for PKCγ and PKCɛ. These studies suggest that individual PKC isozymes play a role in the development of drug dependence and addiction.
Keywords:Protein kinase C  isozymes  ethanol  cocaine  amphetamine  opiates  knockout mouse
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号