Effects of long-term exposure of gelatinated and non-gelatinated cadmium telluride quantum dots on differentiated PC12 cells |
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| Authors: | Babu R Prasad Gillian Mullins Natalia Nikolskaya David Connolly Terry J Smith Valérie A Gérard Stephen J Byrne Gemma-Louise Davies Yurii K Gun'ko Yury Rochev |
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| Affiliation: | (1) National Centre for Biomedical Engineering Science, National University of Ireland Galway, Galway, Ireland;(2) CRANN and the School of Chemistry, Trinity College Dublin, Dublin 2, Ireland |
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| Abstract: | Background The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid (TGA) capped CdTe QDs, were coated with a gelatine layer and investigated in this study with differentiated pheochromocytoma 12 (PC12) cells. The QD - cell interactions were investigated after incubation periods of up to 17 days by MTT and APOTOX-Glo Triplex assays along with using confocal microscopy. |
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