l-tyrosine-binding proteins on melanoma cells |
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Authors: | Andrzej Slominski |
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Institution: | (1) Department of Immunology and Microbiology, Albany Medical College, 12208 Albany, New York |
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Abstract: | Summary Crosslinking of 14C]l-tyrosine to at least five hamster melanoma cell surface proteins is reported. This effect was abolished by addition of nonradioactivel-tyrosine,l-phenylalanine, orl-dopa, but not byd-tyrosine, tyramine, dopamine, norepinephrine, or epinephrine. The above proteins can be purified by tyrosine-affinity chromatography.
They have molecular weights different from proteins staining for dopa oxidase and proteins that bind anti-tyrosinase antibody
in Western blots. It is suggested that they may be a hithergo unrecognized part of the cellular apparatus governing melanogenesis. |
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Keywords: | l-tyrosine" target="_blank">l-tyrosine melanoma melanogenesis |
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