A very efficient bioconversion of soybean phytosterols mixtures to androstanes by mycobacteria |
| |
| Authors: | C Pérez A Falero H Luu Duc Y Balcinde B R Hung |
| |
| Institution: | (1) Department of Biotechnological Processes, National Center for Science Research, PO Box 6990, Havana, Cuba;(2) Laboratory of Steroid, Institute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam |
| |
| Abstract: | The production of several high value steroid drugs, used as progestational, adrenocortical, estrogenic and contraceptive agents, is mostly derived from 4-androstene-dione (AD) and 1,4 androsta-diene-3,17-dione (ADD). Three Vietnamese phytosterols mixtures named VN-1, VN-2 and VN-3, isolated from soybean oil may be efficiently converted into these key compounds by mycobacterial cells. Their general phytosterol composition was 55.39, 70.55, 70.19% for VN-1, VN-2 and VN-3, respectively. Moreover, values of campesterol, β-sitosterol and stigmasterol were determined. After 120 h of shaking in suitable culture media and temperature, maximal yield conversion to ADD was higher than 70% and up to 64% to AD, for the various phytosterols mixtures assays. These results may be better when scaling-up such a procedure of phytosterols conversion. |
| |
| Keywords: | Phytosterols Conversion Mycobacteria AD ADD |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
