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Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template |
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| Authors: | Mogensen John P Jeppesen Lone Bury Paul S Pettersson Ingrid Fleckner Jan Nehlin Jan Frederiksen Klaus S Albrektsen Tatjana Din Nanni Mortensen Steen B Svensson L Anders Wassermann Karsten Wulff Erik M Ynddal Lars Sauerberg Per |
| Institution: | Novo Nordisk A/S, Novo Nordisk Park, 2760 M?l?v, Denmark. jpm@novonordisk.com |
| Abstract: | Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation. |
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