Effects of tumor necrosis factor alpha on sin nombre virus infection in vitro |
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| Authors: | Khaiboullina S F Netski D M Krumpe P St Jeor S C |
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| Affiliation: | Department of Microbiology and Cell and Molecular Biology Program, School of Medicine, University of Nevada-Reno, Reno, Nevada 89557, USA. |
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| Abstract: | Previous data indicate that immune mechanisms may be involved in developing capillary leakage during Sin Nombre virus (SNV) infection. Therefore, we investigated production of tumor necrosis factor alpha (TNF-alpha) by human alveolar macrophages and human umbilical vein endothelial cells (HUVEC) after infection with SNV. In addition, we examined the effect of TNF-alpha on HUVEC monolayer leakage. Our results reveal that although TNF-alpha decreases accumulation of viral nucleoproteins, TNF-alpha levels do not change in SNV-infected cells. In addition, supernatants from SNV-infected human alveolar macrophages did not cause a significant increase in endothelial monolayer permeability. |
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