Mutants ofEmmonsia crescens — Their pathogenicity and size of adiasporesin vivo |
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Authors: | M Hejtmánek J Bárter |
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Institution: | (1) Department of Biology, Faculty of Medicine, Palacky University, 775 00 Olomouc |
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Abstract: | The pathogenicity of seven morphological mutants ofEmmonsia crescens was tested by means of intraperitoneal inoculation in mice. All mutants caused adiaspiromycosis. Adiaspores were isolated
from granulomas after 2 months and their diameters were determined. Adiaspores from granulomas caused by five mutants (M-5,
M-6, M-8, M-9 and M-16) were significantly smaller than adiaspores from granulomas caused by the wild strain, from which the
mutants were derived. Two mutants (M-6 and M-9) produced adiaspores of the smallest diameter (130.5 and 119.9 μm) with the
lowest variance of values, differing thus most from the original wild strain with adiaspores of 230.4 μm in diameter. A positive
correlation was found between the size of the adiasporein vivo and growth rate of the mycelial stage ofEmmonsia crescens in vitro. The mutation characterized by the decreased growth rate of the mycelial stage is pheno-typically manifested in the adiasporic
stage of the life cycle ofEmmonsia crescens, i.e. by the smaller average size of adiaspores in granulomas. |
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