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HCMV infection depress NGF expression in human glioma cells |
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| Authors: | Hai-tao Wang Bin Wang Zhi-jun Liu Zhi-qiang Bai Ling Li Dong-meng Qian Zhi-yong Yan Xu-xia Song |
| Institution: | 1. Department of Microbiology, Qingdao Medical College, and Key Laboratory of Medicine and Biotechnology of Qingdao, Qingdao University Medical College, Qingdao 266071, China;Qingdao Center for Disease control and Prevention, Qingdao 266033, China 2. Department of Microbiology, Qingdao Medical College, and Key Laboratory of Medicine and Biotechnology of Qingdao, Qingdao University Medical College, Qingdao 266071, China 3. LRB 270E, University of Massachusetts Medical School, Worcester, MA. 01605, USA |
| Abstract: | Human cytomegalovirus (HCMV) is the most common cause of congenital infection, resulting in birth defects such as microcephaly. In this study, RT-PCR and Western Blotting were performed to quantify the regulation of endogenic nerve growth factor expression in neuroglia cells by HCMV infection. The results showed that basal, endogenous NGF expression in U251 was unchanged during early HCMV infection. NGF expression is strongly down-regulated during the latent phase of infection. These results suggest that HCMV can depress the NGF expression in U251 cells. |
| Keywords: | Human cytomegalovirus (HCMV) U251 cell Nerve growth factor (NGF) |
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