300 MHz PMR studies on the conformation of the hexanucleotide, 2'OMeGpApApUpApPsi, from the anticodon loop of torula yeast tRNAphe |
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Authors: | G P Kreishman J P Miller P Dea Z Hussain L A Wilson M P Schweizer |
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Affiliation: | ICN Pharmaceuticals, Inc. Nucleic Acid Research Institute 2727 Campus Drive, Irvine, California 92664, USA |
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Abstract: | A complete temperature study of the proton resonances of the hexanucleotide, 2′-OMeGpApApYpApψ, from Torula yeast tRNAphe has been carried out at 300 MHz. The data has been interpreted in terms of a base stacked oligomer in which the glycosyl conformation of the Y-nucleoside changes from syn to anti with temperature increase. An alternative structure for the Y-base is proposed to permit this conformational change. |
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Keywords: | Address correspondence to this author. |
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