Mutator effects in Escherichia coli caused by the expression of specific foreign genes |
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| Authors: | Gabrovsky Vanessa Yamamoto Mitsuko Lynn Miller Jeffrey H |
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| Affiliation: | Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, 90095, USA. |
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| Abstract: | Certain genes from Lactococcus lactis and Pseudomonas aeruginosa, including the nfxB gene, generate a mutator phenotype in Escherichia coli. The results of this study, together with those of a previous study, support conservation of regulatory sequences in E. coli and P. aeruginosa and suggest that some efflux pumps prevent mutagenicity by exporting mutagenic products of metabolism. |
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