5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells |
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| Authors: | G Snyder F Lattanzio P Yadagiri J R Falck J Capdevila |
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| Affiliation: | 1. Glass Eel Production Division, Fisheries Technology Institute, Japan Fisheries Research and Education Agency (FRA), 183-2, Irozaki, Minamiizu, Kamo, Shizuoka 415-0156, Japan;2. Glass Eel Production Division, Fisheries Technology Institute, Japan Fisheries Research and Education Agency (FRA), 205, Natsui, Shibushi, Kagoshima 899-7101, Japan |
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| Abstract: | Luteinizing hormone releasing hormone stimulates the concomitant release of luteinizing hormone and 45Ca2+ from prelabeled anterior pituitary cells. Indomethacin (10 microM) and nordihydroguaiaretic acid (10 microM) had no effect on the luteinizing hormone releasing hormone-stimulated release of either luteinizing hormone or 45Ca2+. Eicosatetraynoic acid (10 microM) blocked both luteinizing hormone releasing hormone-stimulated luteinizing hormone secretion and luteinizing hormone releasing hormone-stimulated 45Ca2+ efflux. 5,6-Epoxyeicosatrienoic acid stimulated both luteinizing hormone secretion and 45Ca2+ efflux from anterior pituitary cells. Additionally, 5,6-epoxyeicosatrienoic acid closely mimics the ability of luteinizing hormone releasing hormone to increase intracellular free calcium. These results are consistent with the hypothesis that 5,6-EET alters calcium homeostasis in a manner similar to that observed during luteinizing hormone releasing hormone stimulation of luteinizing hormone release. |
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