Inhibition of selenium dependent glutathione peroxidase and superoxide dismutase in rats by diethyldithiocarbamate: effect of pre-administration of alpha-tocopherol |
| |
Authors: | Prabhu H Ramachandra Nandini M |
| |
Affiliation: | Department of Biochemistry, Kasturba Medical College, Mangalore 575 001, India. hergaprabhu@rediffmail.com |
| |
Abstract: | Rats pre-administered with alpha-tocopherol (10 mgs/day) for 7 days afforded a significant protection at the tissue level against the lowering of superoxide dismutase and glutathione peroxidase, especially the selenium-dependent glutathione peroxidase. The protective action of alpha-tocopherol in the diethyldithiocarbamate treated rats may be attributed to its antioxidant/free radical scavenging action. It is concluded that selenium-dependent glutathione peroxidase and alpha-tocopherol act in a complementary fashion to block free radical formation. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|