Pharmacologically distinct glutamate receptors on cerebellar granule cells |
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| Authors: | J Drejer T Honoré E Meier A Schousboe |
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| Affiliation: | 1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China;2. Suqian Keylab Biochemical Co., Ltd., Suqian, Jiangsu 223800, China;3. The National Academy of Sciences of Ukraine, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, 1 Murmanska str., Kyiv 02094, Ukraine;4. Oakwood Chemical, Inc. 730 Columbia Hwy. N, Estill, SC 29918, USA;5. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, San Sebastián 20018, Spain;6. IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, Bilbao 48013, Spain;1. Department of Emergency Aid and Disaster Management, Faculty of Health Sciences, Mustafa Kemal University, Hatay, Antakya 31060, Turkey;2. Department of Parasitology, Faculty of Medicine, Mustafa Kemal University, Hatay, Antakya 31060, Turkey |
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| Abstract: | Cultured cerebellar granule cells were found to exhibit calcium-dependent release of 3H-D-aspartate when stimulated with excitatory amino acids. L-glutamate and L-aspartate were found to be potent stimulators of 3H-D-aspartate release, D-aspartate was weaker and only minor effects were seen with D-glutamate, quisqualate, kainate, N-methyl-D-aspartate (NMDA) and L-alpha-aminoadipate (L-alpha AA). It was also found that only L-glutamate and L-aspartate showed high affinity for the 3H-L-glutamate binding sites on granule cell membranes. Stimulation by L-glutamate of 3H-D-aspartate release could be blocked by various excitatory amino acid antagonists. From the relative potencies of agonists and antagonists on D-aspartate release it is suggested that cerebellar granule cells express functionally active glutamate receptors with pharmacological characteristics different from all known excitatory amino acid receptors. |
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