Identification of sodC encoding periplasmic [Cu,Zn]-superoxide dismutase in Salmonella |
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Authors: | James Canvin Paul R Langford Kathryn E Wilks J Simon Kroll |
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Institution: | Molecular Infectious Diseases Group, Department of Paediatrics, Imperial College School of Medicine at St Mary's, London W2 1PG, UK |
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Abstract: | Abstract sodC , encoding Cu,Zn]-cofactored Superoxide dismutase, once thought to be virtually confined to eukaryotes, has now been described in many Gram-negative pathogens that have their primary niche of colonization in the upper respiratory tract. Their role in host-parasite interactive biology is unknown. We here show that members of the major human and animal enteric pathogenic species Salmonella harbour a version of sodC most closely resembling that found in Brucella abortus . The enzyme it encodes is a novel candidate determinant of virulence in Salmonella , an intracellular pathogen potentially exposed to toxic oxygen free radicals within its intracellular niche. |
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Keywords: | Superoxide dismutase Salmonella Periplasm Bacterial [Cu Zn]-superoxide dismutase Bacterial virulence |
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