Development of tripeptidyl farnesyltransferase inhibitors |
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| Authors: | Lee Hee-Yoon Sohn Jeong-Hun Kwon Byoung-Mog |
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| Affiliation: | Center for Molecular Design and Synthesis, Department of Chemistry and School of Molecular Science(BK21), Korea Advanced Institute of Science and Technology, Daejon 305-701, Republic of Korea. leehy@kaist.ac.kr |
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| Abstract: | The first example of tripeptide inhibitors of farnesyltransferase with sub-micromolar inhibition activity was developed based on the fact that CVFM is not a substrate for farnesyltransferase. |
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