肝硬化患者幽门螺杆菌感染与血氨的关系

目的 :探讨幽门螺杆菌 (Hp)感染对肝硬化患者血氨浓度的影响。 方法 :35例肝硬化患者及 2 5例消化性溃疡患者分别测定Hp感染情况及空腹血氨浓度 ,对于Hp阳性病人口服质子泵抑制剂三联方案1周后测定空腹血氨。结果 :Hp阳性的肝硬化患者空腹血氨较Hp阴性的肝硬化患者空腹血氨显著升高(P <0 0 1)。根除Hp后 ,肝硬化患者空腹血氨浓度显著下降 (P <0 0 5 )。 结论 :Hp感染可引起肝硬化患者血氨浓度升高 ,对此类患者采用Hp根除治疗 ,可显著降低血氨浓度。抗Hp治疗可能有助于预防及治疗肝硬化患者的高氨血症及由此诱发的肝性脑病及亚临床肝性脑病。

EFFECT OF HELICOBACTER PYLORI INFECTION ON AMMONIA CONCENTRATIONS IN PATIENTS WITH CIRRHOSIS

Objective:To study Helicobacter pylori(H.pylori)infection on ammonia concentrations in patients with cirrhosis.Methods:35 patients with cirrhosis and 25 patients with peptic uncle were measured Hp and ammonia.All the patients with H.pylori-infectde were given anti-H.pylori medications one week.After eradication therapy for H.pylori,ammonia were measured again.Results:Ammonia concentration in cirrhosis patients who were H.pylori-infected were higher than non H.pylori-infected significantly(P<0.01).After eradication therapy for H.pylori,ammonia concentration in patients with cirrhosis were lower apparently(P<0.05).Conclusion:Our results suggested H.pylori-infected is closely related with hyperammonemia in patientd with cirrhosis.H.pylori eradication can lower ammonia concentrations.H.pylori eradicatiog may be beneficial for therapy and prevent hyperammonemia and hepatic encephalopathy in patients with cirrhosis.