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Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives |
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| Authors: | Bernardelli Patrick Lorthiois Edwige Vergne Fabrice Oliveira Chrystelle Mafroud Abdel-Kader Proust Emmanuelle Pham Nga Ducrot Pierre Moreau François Idrissi Moulay Tertre Anita Bertin Bernadette Coupe Magali Chevalier Eric Descours Arnaud Berlioz-Seux Françoise Berna Patrick Li Mei |
| Institution: | Pfizer Global Research and Development, 3-9 rue de la Loge 94265 Fresnes, France. patrick.bernardelli@aventis.com |
| Abstract: | The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented. |
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