Epstein-barr virus (EBV)-associated antibodies in a case of Burkitt's lymphoma during 14 years of sustained remission |
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| Authors: | P Gunvén G Klein W Henle G Henle G R Pearson |
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| Institution: | (1) Department of Tumor Biology, Karolinska Institutet, S 10401 Stockholm, Sweden;(2) Division of Virology, The Joseph Stokes, Jr. Research Institute, The Children's Hospital of Philadelphia, and School of Medicine, University of Pennsylvania, 19104 Philadelphia, Pa., USA;(3) Department of Microbiology, Mayo Clinic/Foundation, 55901 Rochester, Minn., USA |
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| Abstract: | Summary A Burkitt's lymphoma (BL) patient who sustained remission for more than 14 years after chemotherapy was monitored by means of serial serum samplings. The sera were titrated for antibodies against the Epstein-Barr virus (EBV)-associated cell membrane antigen (MA), viral capsid antigens (VCA), early antigen complex (EA R/D), and nuclear antigen (EBNA), and also for reactivity in the antibody-dependent cellular cytotoxicity (ADCC) test. The initial serological profile corresponded to that of most BL patients with active disease. During remission, it changed to resemble that of normal persons with persistent, latent EBV infection, at least qualitatively. The prognostic and biological implications of the titer levels and their changes are discussed.Abbreviations ADCC
antibody-dependent cellular cytotoxicity
- BCG
Bacillus Calmette-Guérin
- BL
Burkitt's lymphoma
- D
 diffuse component of EA
- EA
Epstein-Barr virus-induced early antigens
- EBNA
Epstein-Barr virus-specific nuclear antigen
- EBV
Epstein-Barr virus
- KCC
Kenya Cancer Council Registry
- MA
EBV-associated cell membrane antigen complex
- NK
natural killer
- R
restricted component of EA
- VCA
EB viral capsid antigen complex |
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