The effect of distamycin A on heterochromatin condensation of Drosophila chromosomes |
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Authors: | Silvana Faccio Dolfini |
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Institution: | (1) Dipartimento di Genetica e di Biologia dei Microrganismi, Universitá di Milano, Via Celoria 26, I-20133 Milano, Italy |
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Abstract: | Larval neuroblasts of four species of Drosophila (melanogaster, hydei, virilis and funebris) were treated with distamycin A, a DNA ligand which induces distinct undercondensation in AT-rich heterochromatin. For each species the patterns of undercondensation were correlated with distribution of quinacrine-bright regions and of satellite DNAs. An overlapping of distamycin A-sensitive and quinacrine-bright heterochromatic regions was demonstrated for D. melanogaster and D. virilis, but not for D. hydei and D. funebris. Distamycin A undercondensation is thus a further criterion for resolving heterochromatin into different parts and enables identification of the steps of the condensation process within heterochromatic regions. |
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