Effect of ACTH on biosynthesis of aldosterone and corticosterone by monolayer cultures of rat adrenal zona glomerulosa cells |
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| Authors: | P J Hornsby M J O'Hare A M Neville |
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| Affiliation: | Chester Beatty Research Institute, Fulham Road, London, SW3 6JB, U.K. |
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| Abstract: | A method is described for preparing monolayer cultures of zona glomerulosa cells isolated from the rat adrenal cortex. Aldosterone and corticosterone were secreted by the cultures when maintained with medium containing 11 mM K+. ACTH, while stimulating aldosterone biosynthesis at first, did not maintain its long-term secretion, yet caused corticosterone production to rise to a steadily maintained level. The significance of this effect is discussed. |
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