首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Mucins and TFF peptides of the tear film and lacrimal apparatus
Authors:Paulsen Friedrich P  Berry Monica S
Institution:Department of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Grosse Steinstr. 52 06097 Halle (Saale), Germany. friedrich.paulsen@medizin.uni-halle.de
Abstract:The three-dimensional organization of the tear film, which is produced and drained by the different structures of the ocular adnexa, is essential for maintainance and protection of the ocular surface. This is facilitated by a class of large, highly glycosylated, hydrophilic glycoproteins, the mucins, which are usually expressed in association with a class of peptides having a well-defined, structurally conserved trefoil domain, the mammalian trefoil factor family (TFF) peptides. In this review, the latest information regarding mucin and TFF peptide function and regulation in the human lacrimal system, the tear film and the ocular surface is summarized with regard to mucous epithelia integrity, rheological and antimicrobial properties of the tear film and tear outflow, age-related changes and certain disease states such as dry eye, dacryostenosis and dacryolith formation.
Keywords:Conjunctiva  Cornea  Dry eye  Lacrimal apparatus  Lacrimal gland  MUC  Mucin  Nasolacrimal ducts  Ocular surface  Precorneal tear film  Preocular fluid  Rheology  Tear film  Tear outflow  TFF peptides
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号