The role of bacterial pili in protein and DNA translocation. |
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| Authors: | R Koebnik |
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| Institution: | 1. Division of Molecular Biology, Center for Food Safety Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA;2. Division of Microbiology, Center for Food Safety and Applied Nutrition, U S Food and Drug Administration, College Park, MD 20740, USA;3. Division of Animal and Food Microbiology, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA;4. National Antimicrobial Resistance Monitoring System,Center for Veterinary Medicine, U. S. Food Drug Administration, Laurel, MD 20708, USA |
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| Abstract: | Gram-negative bacteria have surface appendages that assemble via different secretion machineries. Recently, new experimental approaches have contributed to a better understanding of the molecular mechanisms of flagellar and pilus assembly, and protein secretion. These findings can be applied to plant pathogenic bacteria, which probably transfer effector proteins directly into their eukaryotic host cells. Here, it is suggested that assembly of Hrp pili occurs in the periplasm and that unfolded effector proteins attach to pilins within the pili, thus effecting protein translocation. A two-domain structure for the HrpA pilin from Pseudomonas syringae is also predicted. |
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