Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue |
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Authors: | Eiras Sonia Teijeira-Fernández Elvis Shamagian Lilian Grigorian Fernandez Angel Luis Vazquez-Boquete Angel Gonzalez-Juanatey Jose Ramon |
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Institution: | aUnit of Cellular and Molecular Research on Cardiology, Universitary Clinical Hospital of Santiago de Compostela, Spain;bCardiology Department and Coronary Unit, Universitary Clinical Hospital of Santiago de Compostela, Spain;cHeart Surgery Department, Universitary Clinical Hospital of Santiago de Compostela, Spain;dPathology Department, Universitary Clinical Hospital of Santiago de Compostela, Spain |
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Abstract: | Epicardial adipose tissue (EAT) expresses lower levels of adiponectin in patients with CAD and higher levels of inflammatory mediators such as IL-6 and leptin than subcutaneous adipose tissue. This showed one important role of EAT in coronary artery disease. However, the relationship of EAT adiponectin and IL-6 levels to the extension of coronary artery disease has not hitherto been determined. We sought to determine whether the levels of adiponectin and interleukin-6 (IL-6) mRNA in epicardial adipose tissue are associated with the extension of coronary artery disease (CAD). Methods: Angiographic and hormones expression were evaluated from epicardial and subcutaneous adipose tissue. 92 patients (58 CAD, 34 non-CAD) who underwent cardiac surgery. Adiponectin and IL-6 mRNA levels were measured by real time RT-PCR in epicardial and subcutaneous adipose tissue (SAT) following angiographic evaluation of their coronary arteries. Results: We found that epicardial adipose tissue of CAD expressed lower levels of adiponectin mRNA and higher levels of IL-6 mRNA than that of non-CAD patients. As the number of injured arteries rose, adiponectin mRNA levels decreased (r = −0.402, p < 0.001) and IL-6 mRNA increased (r = 0.514, p < 0.001) in epicardial adipose tissue. Conclusions: The extension of CAD is significantly associated with the expression of adiponectin and IL-6 mRNA in EAT. These findings suggest that low adiponectin and high IL-6 expression by EAT may contribute to CAD extension. |
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Keywords: | Epicardial fat Extension of coronary artery |
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