Water-soluble propofol analogues with intravenous anaesthetic activity |
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| Authors: | Cooke A Anderson A Buchanan K Byford A Gemmell D Hamilton N McPhail P Miller S Sundaram H Vijn P |
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| Affiliation: | Department of Medicinal Chemistry and Pharmacology, Organon Laboratories Ltd., Newhouse, Scotland, UK. a.cooke@organon.nhe.akzonobel.nl |
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| Abstract: | Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents. |
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