Common variant (rs9939609) in the<Emphasis Type="Italic"> FTO</Emphasis> gene is associated with metabolic syndrome |
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Authors: | Donghao?Zhou Hongjun?Liu Ming’ai?Zhou Shengxiang?Wang Jingling?Zhang Email author" target="_blank">Lin?LiaoEmail author Email author" target="_blank">Fang?HeEmail author |
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Institution: | (1) Department of Endocrinology, Linyi People’s Hospital, Linyi, 276000, China;(2) 120 Emergency Command Center of Linyi City, Linyi, 276002, China;(3) Department of Endocrinology, Medicine School of Shandong University, Jinan, 250012, China;(4) Department of Immunology and Rheumatology, Linyi Hospital of Traditional Chinese Medicine, Linyi, 276002, China;(5) Division of Endocrinology, Department of Medicine, Qianfoshan Hospital Affiliated to Shandong University, Jinan, 250001, China; |
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Abstract: | Recent genome-wide association studies have showed that common variant (rs9939609) in fat mass and obesity associated (FTO) gene was significantly associated with type 2 diabetes through an effect on human body mass index/obesity. Further studies
have suggested that this variant was also involved in the development of metabolic syndrome (MetS). However, the results have
been inconsistent. In this study, we performed a meta-analysis to clarify the association between rs9939609 polymorphism and
the risk of MetS. Published literature from PubMed, EMBASE and other databases were searched. All studies assessing the association
between rs9939609 polymorphism and the risk of MetS were identified. Pooled odds ratio (OR) with 95% confidence interval (CI)
was calculated using fixed-effects model. Thirteen studies (8,370 cases and 23,156 controls) using NCEP ATPIII criteria for
MetS were pooled with a meta-analysis. The overall result showed that there was a statistically significant association between
rs9939609 polymorphism and MetS risk (OR = 1.11, 95% CI = 1.06–1.17). Subgroup analysis based on ethnicity showed that effect
size was only statistically significant in Europeans (OR = 1.11, 95% CI = 1.05–1.16). Eight studies (1,256 cases and 2,551
controls) using IDF criteria for MetS were pooled with a meta-analysis. The overall analysis suggested that rs9939609 polymorphism
was significantly associated with MetS risk (OR = 1.32, 95% CI = 1.13–1.54). Subgroup analysis stratified by ethnicity suggested
that effect size was only statistically significant in Asians (OR = 1.33, 95% CI = 1.10–1.61). Our results suggested that
FTO rs9939609 polymorphism was significantly associated with the increased risk of MetS in European and Asian populations. Mechanistic
investigation is also needed to clarify the effect of FTO gene in the predisposition to MetS. |
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