Photophysics of novel coumarin-labeled depsipeptides in solution: sensing interactions with SDS micelle via TICT model |
| |
Authors: | Suvendu Biswas Ilker Avan Akash K. Basak Nader E. Abo-Dya Abdullah Asiri Alan R. Katritzky |
| |
Affiliation: | 1. Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL, 32611-7200, USA 2. Department of Chemistry, Faculty of Science, Anadolu University, 26470, Eski?ehir, Turkey 3. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt 4. Department of Chemistry, King Abdulaziz University, Jeddah, 21589, Saudi Arabia
|
| |
Abstract: | N-Acylbenzotriazoles enable the synthesis (69–92 % yield) of blue to green fluorescent coumarin-labeled depsidipeptides 8a–f (quantum yields 0.004–0.97) and depsitripeptides 12a–d (quantum yields 0.02–0.96). Detailed photophysical studies of fluorescent coumarin-labeled depsipeptides 8a–f and 12a–d are reported for both polar protic and polar aprotic solvents. 7-Methoxy and 7-diethylaminocoumarin-3-ylcarbonyl depsipeptides 8c,f and 12d are highly solvent sensitive. These highly fluorescent compounds could be useful for peptide assays. Further photophysical studies of 7-diethylaminocoumarin-labeled depsipeptides 8c,12d within the micellar microenvironment of SDS reflect their ability to bind with the biological membrane, suggesting potential applications in the fields of bio- and medicinal chemistry. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|