Fast atom bombardment: evidence of disproportionation and recombination of a synthetic porphyrin in the matrix |
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| Authors: | L Kurlansik T J Williams J E Campana B N Green L W Anderson J M Strong |
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| Institution: | Naval Medical Research Institute, Bethesda, Maryland 20814 USA;Naval Research Laboratory, Chemistry Division, Washington, D.C. 20375 USA;VG Analytical, Ltd., Tudor Road, Altrincham, Cheshire, WA14, U.K.;Laboratory of Medicinal Chemistry and Pharmacology, National Cancer Institute Bethesda, Maryland 20814 USA |
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| Abstract: | In addition to dimerization and polymerization of samples as previously suggested, it appears that during FAB-MS, reactions in the sample matrix can occur to yield new compounds that are recombinations of molecular fragments. This type of reaction may be especially critical to the integrity of peptide sequencing using FAB, since the reactions cited in this report involve the formation and rupture of amides or peptide bonds. |
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| Keywords: | EGTA ethyleneglycol-bis (β-amino-ethyl) N N tetraacetic acid |
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