Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba |
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Authors: | Jian-Chun Qin Jin-Ming Gao Ya-Mei Zhang Ming-Sheng Bai Hartmut Laatsch |
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Affiliation: | a College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China b Department of Orgnic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany c College of Life Sciences, Northwest A & F University, Yangling, Shaanxi 712100, China d Center for Experiments & Education Technology, Linyi Normal University, Linyi, Shandong 276005, China |
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Abstract: | A novel polyhydroxylated C29-sterol, 25ξ-methyl-22-homo-5α-cholest-7,22-diene-3β,6β,9α-triol, designated globosterol (1), together with one known tetrahydroxylated ergosterol (22E, 24R)-ergosta-7,22-diene-3β,5α,6β,9α-tetraol (2) has been isolated from the cultures of an endophytic fungus, Chaetomium globosum ZY-22 originated from the plant Ginkgo biloba. The structures and relative configurations of 1 and 2 were established on the basis of extensive spectroscopic analyses including 1D and 2D NMR (1H-1H COSY, HSQC, HMBC, and NOESY) experiments and comparison with the literature. Globosterol (1) possesses an unprecedented 25-methyl Δ22-C10-side chain and Δ7-3β,6β,9α-hydroxy-steroid nucleus, which represents the first example for C29-steroids of the group. |
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Keywords: | Ginkgo biloba Endophytic fungus Chaetomium globosum Polyhydroxysterol 25ξ-Methyl-22-homo-5α-cholest-7,22-diene-3β,6β,9α-triol Globosterol |
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