|
|||||
|
|
New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli |
|
| Authors: | Shi-Yie Cheng Zhi-Hong Wen Chi-Hsin Hsu Shang-Kwei Wang Chang-Yih Duh |
| Affiliation: | a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan b Center of Asia-Pacific Marine Research, National Sun Yat-sen University, Kaohsiung, Taiwan c Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan d Institute of Oceanography, National Taiwan University, Taipei, Taiwan |
| Abstract: | Chemical investigation of the Formosan soft coral Nephthea chabroli resulted in the isolation of four new 19-oxygenated steroids, nebrosteroids I-L (1-4), together with a new 4α-methylated steroid, nebrosteroid M (5). The molecular structures of these isolated metabolites were elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Compounds 1-5 were evaluated for anti-inflammatory activity using RAW 264.7 macrophages. |
| Keywords: | Nephthea chabroli 19-Oxygenated steroids 4α-Methylated steroid Anti-inflammatory activity RAW 264.7 macrophages |
| 本文献已被 ScienceDirect 等数据库收录！ | |