Synthesis and antimicrobial evaluation of bile acid tridentate conjugates |
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| Authors: | Liliang Huang Yanhong Sun Yuanqing Zhang Jia Xu |
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| Institution: | a Radiopharmaceuticals Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
b Graduate School of the Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Two series of novel bile acid tridentate conjugates with different linkers were synthesized and characterized, and their biological activities in vitro were evaluated. The procedure was straightforward and efficient to be carried out with high overall yield. The antimicrobial activity of the synthesized compounds against Saccharomyces cerevisiae, Aspergillus niger, Escherichia coli and Staphylococcus aureus was investigated in vitro. The best activity of minimal inhibitory concentrations (MICs) for 1c, 1c′, 2c and 2c′ against S. cerevisiae was up to 0.125 μg/mL. |
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| Keywords: | Bile acids Tridentate conjugates Antimicrobial activity |
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