Synergistic Effects of Arsenic Trioxide and Silibinin on Apoptosis and Invasion in Human Glioblastoma U87MG Cell Line |
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Authors: | Majid Zaki Dizaji Mohsen Malehmir Ardeshir Ghavamzadeh Kamran Alimoghaddam Seyed H Ghaffari |
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Institution: | (1) Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; |
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Abstract: | Patients with glioblastoma multiforme (GBM) have poor therapeutic outcomes despite their current therapy. In an attempt to
increase the efficacy of therapy for GBM, we studied the efficacy of arsenic trioxide (ATO), a newly introduced treatment
for glioma, combined with silibinin, a natural polyphenolic flavonoid, in the GBM cell line, U87MG. The combination therapy
synergically inhibited metabolic activity, cell proliferation, and gelatinase A and B activities; it also increased apoptosis.
Additionally, it decreased the mRNA level of cathepsin B, uPA, matrix metalloproteinase-2 and 9, membrane type 1-MMP, survivin,
BCL2, CA9; it increased mRNA level of caspase-3. Altogether, these results showed that ATO and silibinin in some cases improved
and/or complemented the anticancer effects. This study may supply insight into the design of new combination cancer therapies
to cells intrinsically less sensitive to routine therapies and suggested a new combination therapy for the highly invasive
human glioma treatment. |
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