Confirmation by Chemical Synthesis of the Structure of 4-Ipomeanol,a Lung-toxic Metabolite of the Sweet Potato, Ipomoea batatas |
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| Authors: | MICHAEL R. BOYD BENJAMIN J. WILSON THOMAS M. HARRIS |
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| Affiliation: | 1.Department of Pharmacology, Division of Toxicology, School of Medicine, Department of Chemistry,Vanderbilt University,Nashville;2.Division of Toxicology, School of Medicine, Department of Chemistry,Vanderbilt University,Nashville;3.Department of Chemistry,Vanderbilt University,Nashville |
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| Abstract: | WE have described the lung and liver toxicity of mould-damaged sweet potatoes and characterized briefly some abnormal metabolites responsible for these phenomena1–4. The respiratory tract toxin, 4-ipomeanol (1-[3-furyl]-4-hydroxy-1-pentanone) (VI), may be responsible for the typical lung oedema of cattle that are fed mouldy sweet potatoes as well as a similar pathological state in mice fed or injected with the pure compound. |
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