Carnitine and trimethylaminobutyrate synthesis in rat tissues (Short Communication) |
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| Authors: | Richard A. Cox and Charles L. Hoppel |
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| Affiliation: | Departments of Pharmacology and Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, U.S.A. |
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| Abstract: | Liver and testis slices convert 6-N-trimethyl-lysine into 4-N-trimethylaminobutyrate and carnitine. Adipose, skeletal muscle, heart, or kidney tissues metabolize trimethyl-lysine into trimethylaminobutyrate but not into carnitine. Trimethylaminobutyrate hydroxylation, forming carnitine, occurs in liver and to a minor degree in testis. Liver is the primary site of carnitine biosynthesis in the rat. |
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