DNA strand scission by a Cu(I).adenylated polymeric template: preliminary mechanistic and recycling studies |
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Authors: | Verma Sandeep Srivatsan S G Claussen Craig A Long Eric C |
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Institution: | Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur 208016 (UP), India. sverma@iitk.ac.in |
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Abstract: | Cleavage of a model phosphate ester and supercoiled plasmid DNA by a Cu(I).adenylated polymer template and preliminary mechanistic investigations are reported. A novel paradigm for the design of recyclable nucleolytic reagents allowing multiple use of this catalyst is also demonstrated |
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