Mutation Indy p115 Extends Life Span in Adult Drosophila melanogaster Depending on Sex and Genetic Background

The Indy ^p115 allele in heterozygous state almost doubles the life span of adult Drosophila melanogaster, and this effect largely depends on the strain used for obtaining heterozygotes. Male and female life span depends on Indy ^p115 to a different degree. Apart from Indy ^p115 heterozygotes, sexual dimorphism for life span was also observed in strain Hikone-AW, but not in Oregon R and TM3 balancer. In heterozygotes Indy ^p115/OR, both the average life span and female reproductive period increased as compared to OR control. No substantial increase in female reproductive period in Indy ^p115/Hk heterozygotes was found. In homozygotes for allele Indy ^p115, we have previously revealed two phases of embryotic lethality and lethality at the larval and pupa stages. Thus, allele Indy ^p115 has a double and opposite effect on Drosophilaviability. On the one hand, it extends the life span of adult flies, on the other, decreases survival at preimaginal stages.