Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of <Emphasis Type="Italic">Streptococcus pneumoniae</Emphasis> |
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| Authors: | Francesca De Paolis Elisa Beghetto Andrea Spadoni Francesca Montagnani Franco Felici Marco R Oggioni Nicola Gargano |
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| Institution: | (1) Kenton laboratories, Kenton Srl, Rome, Italy;(2) Department of Molecular Biology, University of Siena, Italy;(3) Department of Microbiology, Genetics and Molecular Biology, University of Messina, Italy |
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| Abstract: | Background The IgA1 protease of Streptococcus pneumoniae is a proteolytic enzyme that specifically cleaves the hinge regions of human IgA1, which dominates most mucosal surfaces
and is the major IgA isotype in serum. This protease is expressed in all of the known pneumococcal strains and plays a major
role in pathogen's resistance to the host immune response. The present work was focused at identifying the immunodominant
regions of pneumococcal IgA1 protease recognized by the human antibody response. |
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