Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis |
| |
| Authors: | Tomokazu Shirai Koki Fujimura Chikara Furusawa Keisuke Nagahisa Suteaki Shioya Hiroshi Shimizu |
| |
| Affiliation: | (1) Department of Biotechnology, Graduate School of Engineering, Osaka University, Japan;(2) Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Japan |
| |
| Abstract: | Background Corynebacterium glutamicum has several anaplerotic pathways (anaplerosis), which are essential for the productions of amino acids, such as lysine and glutamate. It is still not clear how flux changes in anaplerotic pathways happen when glutamate production is induced by triggers, such as biotin depletion and the addition of the detergent material, Tween 40. In this study, we quantitatively analyzed which anaplerotic pathway flux most markedly changes the glutamate overproduction induced by Tween 40 addition. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
