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Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis |
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| Authors: | Ashwini L Chand Andrew S Murray Rebecca L Jones Natalie J Hannan Lois A Salamonsen Luk Rombauts |
| Affiliation: | (1) Prince Henry's Institute of Medical Research, PO Box 5152, 3168 Clayton, Victoria, Australia;(2) Department of Obstetrics and Gynaecology, Monash University, PO Box 5152, 3168 Clayton, Victoria, Australia;(3) Division of Human Development, Academic Unit of Child Health, University of Manchester, St Mary's Hospital Research Floor, Hathersage Road, M13 OJH Manchester, Victoria, UK;(4) Wellington School of Medicine, Otago University, Wellington, Wellington, New Zealand |
| Abstract: | BackgroundUnderstanding the pathophysiology of chemokine secretion in endometriosis may offer a novel area of therapeutic intervention. This study aimed to identify chemokines differentially expressed in epithelial glands in eutopic endometrium from normal women and those with endometriosis, and to establish the expression profiles of key chemokines in endometriotic lesions. |
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