Correlation between the compact regions predicted by the Average Distance Map (ADM) and the biologically active sites in atrial natriuretic peptide |
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Authors: | Takeshi Kikuchi |
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Affiliation: | (1) Analytics and Informatics Department, International Research Laboratories, Ciba-Geigy(Japan) Limited, 10–66 Miyuki-cho, 665 Takarazuka, Japan |
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Abstract: | The prediction of the short-range compact regions of human atrial natriuretic peptide (a-hANP), one of the biologically active peptides, has been made by means of the Average Distance Map(ADM). We found out that the location of the predicted short-range compact regions is consistent with the structural units determined by the NMR analysis (Kobayashiet al., 1988). Furthermore, the short-range compact regions correspond well to the biologically active areas of atriopeptin (103–125)-amide (which is homologous peptide toa-hANP), detected by the glycine substitution technique (Konishiet al., 1987). The results suggest that a predicted short-range compact region can be regarded as a possible active site in a biologically active peptide. |
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Keywords: | Average distance map compact region biologically active peptide active site |
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