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In vitro and in vivo evaluation of O-alkyl derivatives of tramadol |
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| Authors: | Shao Liming Hewitt Michael Jerussi Thomas P Wu Frank Malcolm Scott Grover Paul Fang Kevin Koch Patrick Senanayake Chris Bhongle Nandkumar Ribe Seth Bakale Roger Currie Mark |
| Affiliation: | Sepracor Inc., Medicinal Chemistry, 84 Waterford Drive, Marlborough, MA 01752, USA. Liming.shao@sepracor.com |
| Abstract: | Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency. |
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