|
|||||
|
|
Discovery of novel FMS kinase inhibitors as anti-inflammatory agents |
|
| Authors: | Illig Carl R Chen Jinsheng Wall Mark J Wilson Kenneth J Ballentine Shelley K Rudolph M Jonathan DesJarlais Renee L Chen Yanmin Schubert Carsten Petrounia Ioanna Crysler Carl S Molloy Christopher J Chaikin Margery A Manthey Carl L Player Mark R Tomczuk Bruce E Meegalla Sanath K |
| Institution: | Johnson & Johnson Pharmaceutical Research & Development, Welsh & McKean Roads, Spring House, PA 19477, USA. |
| Abstract: | The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |