Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold |
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| Authors: | Coumar Mohane Selvaraj Wu Jian-Sung Leou Jiun-Shyang Tan Uan-Kang Chang Chung-Yu Chang Teng-Yuan Lin Wen-Hsing Hsu John T-A Chao Yu-Sheng Wu Su-Ying Hsieh Hsing-Pang |
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| Institution: | Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC. |
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| Abstract: | Tricyclic 6,7-dihydro-4H-pyrazolo1,5-a]pyrrolo3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition. |
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