分子生物学法分析青少年甲状腺肿物临床病理及特点

探讨青少年甲状腺肿物的临床病理学特点,甲状腺癌的复发、转移和结节性甲状腺肿复发的可能相关因素。按WHO病理分型标准和国际抗癌联盟(UICC)TNM分期标准回顾性分析青少年甲状腺肿物124例及其中部分甲状腺癌和结节性甲状腺肿的随访资料。124例甲状腺肿物患者男女比例约为1 3,甲状腺癌39例(31.5%),其中乳头状癌35例,滤泡癌3例,髓样癌1例;甲状腺腺瘤59例(47.6%),结节性甲状腺肿11例(8.9%),结节性甲状腺肿伴腺瘤7例(5.6%),甲状腺炎5例(4%),甲状舌管囊肿3例(2.4%)。本组资料显示,青少年甲状腺癌以乳头状癌为主,其复发、转移与组织学亚型为弥漫硬化型及甲状腺包膜和其外软组织受侵状态相关。虽然常见淋巴结转移、肺转移以及局部侵犯周围软组织,但患者总体预后较好。结节性甲状腺肿的复发与病变弥漫位于双叶有关,而与患者性别、年龄和是否伴有乳头样及腺瘤样增生关系不密切。

Molecular Biology Analysis of Clinical Pathology of Goiters and Its Characteristics in Teenagers

Clinical pathology characteristics,recurrence of thyroid carcinoma,metastasis and possibly related factors of the recurrence of nodular goiter were analyzed.Followed up visit materials of 124 cases of teenagers＇ goiters and of parts of thyroid carcinoma and nodular goiters were analyzed according to WHO＇s pathological type classification standard and UICC TNM standards by stages,and follow-up was conducted in some of the cases of thyroid carcinoma and nodular goiter were analyzed.The results showed that goiter patients ratio of male to female in the 124 cases was about 13;and were composed of 39 cases of thyroid carcinoma（31.5%）,among them papillary carcinoma was 35 cases,follicular carcinoma was 3,and medullary carcinoma was 1;59 thyroid adenoma（47.6%） and 11 nodular goiter（8.9%）.Therefore,materials in this group demonstrated that thyroid carcinoma in teenagers mainly was papillary carcinoma.The recurrence and metastasis were related to the state of infection of thyroid membrane and outer soft tissue diffuse-sclerotic being histological subtype,however,their prognosis was relatively good although lymphoid and lung metastasis,and local invasion were common.Recurrence of nodular goiter was associated with diffusion pathology located in both lobes,but not closed related to patients＇ gender,age,and whether or not accompanied with papillary and adenomatoid hyperplasia.