|
|||||
|
|
Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains |
|
| Authors: | Er-Ying Zhao Hong-Xia Bao Le Tang Qing-Hua Zou Wei-Qiao Liu Da-Ling Zhu Jessica Chin Ying-Ying Dong Yong-Guo Li Feng-Lin Cao Cornelis Poppe Kenneth E Sanderson Randal N Johnston Daoguo Zhou Gui-Rong Liu Shu-Lin Liu |
| Institution: | 1. Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, 150081, Harbin, China 5. HMU-UCFM Centre for Infection and Genomics, Harbin Medical University, Harbin, China 2. Department of Microbiology, Peking University Health Science Center, Beijing, China 10. Department of Neurology, Vancouver General Hospital, Vancouver, Canada 3. Departments of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada 4. Department of Biopharmaceuticals, Faculty of Pharmacy, Harbin Medical University, Harbin, China 6. Genetic Diagnosis Laboratory of First Hospital, Harbin Medical University, Harbin, China 7. Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, ON, Canada 8. Departments of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada 9. Department of Biological Sciences, Purdue University, West Lafayette, IN, USA |
| Abstract: | DT104 emerged as a new branch of Salmonella typhimurium with resistance to multiple antimicrobials. To reveal some general genomic features of DT104 for clues of evolutionary events possibly associated with the emergence of this relatively new type of this pathogen, we mapped 11 independent DT104 strains and compared them with non-DT104 S. typhimurium strains. We found that all 11 DT104 strains contained three insertions absent in non-DT104 strains, i.e., the previously reported ST104, ST104B and ST64B. However, SGI-1, a genomic island known to be responsible for DT104 multidrug resistance, was not present in all DT104 strains examined in this study: one DT104 strain did not contain SGI-1 but carried a 144 kb plasmid, suggesting possible evolutionary relationships between the two DNA elements in the development of antimicrobial resistance. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |