Nitrendipine is a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes. |
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Authors: | J C Ellory K Kirk S J Culliford G B Nash J Stuart |
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Affiliation: | University Laboratory of Physiology, University of Oxford, UK. |
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Abstract: | Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipine inhibited K+(86Rb+) influx with an I50 of around 130 nM. Similar results were obtained for K+(86Rb+) efflux, and for K+(86Rb+) influx into cells suspended in a high-K+ medium. |
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