Mitochondrial dynamics in the regulation of neuronal cell death |
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Authors: | Eric C C Cheung Heidi M McBride Ruth S Slack |
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Institution: | (1) University of Ottawa, Department of Cellular Molecular Medicine, Ottawa Health Research Institute, 451 Smyth Road, Ottawa, Ontario, K1H 8M5;(2) University of Ottawa Heart Institute, Canada |
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Abstract: | Mitochondria undergo continuous fission and fusion events in physiological situations. Fragmentation of mitochondria during
cell death has been shown to play a key role in cell death progression, including release of the mitochondrial apoptotic proteins.
Ultrastructural changes in mitochondria, such as cristae remodeling, is also involved in cell death initiation. Here, we emphasize
the important role of mitochondrial fission/fusion machinery in neuronal cell death. Unlike many other cell types such as
immortalized cell lines, neurons are distinct morphologically and functionally. We will discuss how this uniqueness presents
special challenges in the cellular response to neurotoxic stresses, and how this affects the mitochondrial dynamics in the
regulation of cell death in neurons. |
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Keywords: | Apoptosis Mitochondria Mitochondrial fission/fusion Neurons Excitotoxicity Oxidative stress DNA damage |
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