Chaephilones A and B,Two New Azaphilone Derivatives Isolated from Chaetomium globosum |
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| Authors: | Chunmei Chen Jing Wang Hucheng Zhu Jianping Wang Yongbo Xue Guangzheng Wei Yi Guo Dongdong Tan Jinwen Zhang Chunping Yin Yonghui Zhang |
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| Institution: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China;2. Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. 3. R. China |
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| Abstract: | Two new azaphilone derivatives, chaephilones A ( 1 ) and B ( 2 ), were isolated from the fungus Chaetomium globosum, together with four structurally related analogs 3 – 6 . The structures of 1 and 2 were elucidated by comprehensive spectroscopic analyses including HR‐ESI‐MS and NMR. The known compounds were identified as chaetomugilin Q ( 3 ), chaetomugilin D ( 4 ), 11‐epichaetomugilin A ( 5 ), and chaetomugilin S ( 6 ) by comparing their NMR data and optical rotation values with those reported. Compound 2 represents the first example of azaphilone with an open furan ring. Compounds 1 and 2 were evaluated for cytotoxic activities against five human cancer cell lines (HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480) by the MTS method. |
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| Keywords: |
Chaetomium globosum
Azaphilone derivatives Chaephilones A and B |
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