Inhibition of mammalian 5-lipoxygenase by 2-benzylaminophenols |
| |
Authors: | D R Buckle J Bumstead G D Clarke K A Foster H Parr J F Taylor V E Thody R A Webster |
| |
Affiliation: | Beecham Pharmaceuticals, Research Division, Biosciences Research Centre, Epsom, Surrey, UK. |
| |
Abstract: | A number of 2-benzylaminophenols, prepared from the corresponding 2-aminophenols by reductive alkylation, have been identified as highly potent inhibitors of 5-lipoxygenase with IC50 values in the nanomolar range. Most compounds were also shown to inhibit the release of the peptidoleukotrienes when administered intraperitoneally in a rat model of peritoneal anaphylaxis. Two compounds evaluated for their effects on anaphylactic contractions in isolated human lung were shown to attenuate the leukotriene-induced component of the response. |
| |
Keywords: | |
|
|