Nuclear protein synthesis in regenerating rat liver : Selective histone inhibition by α-amanitin |
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Authors: | Francesco Novello Annalisa Pession-Brizzi Massimo Derenzini |
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Abstract: | Nuclear protein synthesis has been studied in regenerating rat hepatocytes after partial hepatectomy and α-amanitin treatment. The toxin induced a marked and precocious inhibition of histone synthesis without affecting the acidic nuclear proteins. This inhibition preceded the inhibition of DNA synthesis. The modification of polyribosome profile and of [14C]lysine incorporation on synthesized polypeptides were consistent with a reduction of specific mRNAs. |
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