Estradiol plus progesterone treatment and precopulatory behavior in prepubertally ovariectomized female rats: dose-response relationships |
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| Authors: | Z Hlinák |
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| Affiliation: | 1. MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China;2. Department of Environmental Engineering, Quzhou University, Quzhou 324000, China;3. Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium;4. Department of Effect-Directed Analysis, Helmholtz Centre for Environmental Research — UFZ, Leipzig, 04318, Germany;1. Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, PR China;2. Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario K1A 0H3, Canada |
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| Abstract: | The copulatory and precopulatory behavioral repertoire expressed in terms of the intensity scale of sexual responsiveness was investigated in female rats ovariectomized on the 30th day after birth and treated for 9 weeks, once weekly, with estradiol dipropionate (5, 10, 15, 20, and 30 micrograms per animal) plus progesterone (in the range from 0.0 to 2.4 mg per animal). It was found that the higher the dosage of estradiol and progesterone used, the more complete the precopulatory behavioral pattern that was induced. Further, the same level of sexual responsiveness was achieved by various combinations of both hormones used. The dose-response relationships are less complicated in prepubertally ovariectomized females in comparison with those spayed as adults. Finally, the most complete pattern, characterized by ritualized darting, was not achieved at all. |
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